Have you ever had any issues with those on c7 becoming vit B deficient and/or do they supplement with Vit B? I was curious because I noticed that Biotin is needed when Propinal Co A is converted into D-methyl malonyl CoA and B12 is needed for the conversion of L-methylmalonyl CoA to Succinyl CoA.
Biotin (one of the B vitamins; B7) is necessary for the enzyme propionyl-CoA carboxylase and to funnel C3 into the TCA cycle. It is very efficiently recycled by the body and we have never seen a problem with biotin deficiency in patients on C7. Hope this helps. Dr. Vockley