Neuropathic Symptoms Partially Reversible in LCFAOD, Expert Says

Neuropathic symptoms may be at least partially reversible in patients with long chain fatty acid oxidation disorders (LCFAOD), according to new research.

Sarah Grunert, MD. Credit: International Network for Fatty Acid Oxidation Research and Management (INFORM)

Speaking at the International Network for Fatty Acid Oxidation Research and Management (INFORM) Virtual Meeting held October 27-28, 2021, Sarah Grunert, MD, stated that neuropathic symptoms in patients with long chain 3-hydroxyacyl CoA dehydrogenase deficiency (LCHADD) and mitochondrial trifunctional protein deficiency (MTPD) may be reversible in patients with acute metabolic deterioration and acute onset of neuropathy.

Dr. Grunert, from the Metabolic Center of the University Children’s Hospital in Freiburg, Germany, presented findings from her retrospective study involving 8 LCHAD-deficient and 11 MTPD patients.