Insights Into the Cardiac Consequences of FAO Deficiency

Long-chain fatty acid β-oxidation (FAO) deficiency disturbs amino acid metabolism and interferes with cardiac metabolic signaling in long-chain acyl-CoA dehydrogenase (LCAD) knockout (KO) mice, researchers reported. The LCAD KO mouse mimics prominent symptoms of human long chain fatty acid oxidation disorders (LCFAOD), such as very long-chain acyl-CoA dehydrogenase deficiency (VLCAD) and carnitine palmitoyltransferase 2 (CPT2) deficiency.

Pablo Ranea-Robles, PhD, first-author of the publication “A mitochondrial long-chain fatty acid oxidation defect leads to uncharged tRNA accumulation and activation of the integrated stress response in the mouse heart.”, presented the results of the study at the INFORM Lecture Series, virtually held on September 20, 2021. A preprint version of the publication is available on bioRxiv.

By |2021-10-08T13:09:58-04:00September 27th, 2021|
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