Insights Into Fatty Acid Oxidation and Insulin Sensitivity in LCFAOD Patients

In a new study, long chain fatty acid oxidation disorders (LCFAOD) prevented Intralipid-induced insulin resistance in the liver but did not prevent insulin resistance in peripheral tissue. LCFAOD also did not prevent intramyocellular lipid (IMCL) accumulation in the periphery.

Melanie Gillingham, PhD, RD, LD Credit: International Network for Fatty Acid Oxidation Research and Management

The results were presented during the International Network for Fatty Acid Oxidation Research and Management (INFORM) Virtual Conference by Melanie Gillingham, PhD, RD, LD, associate professor of Molecular and Medical Genetics, School of Medicine, at Oregon Health and Science University in Portland. In her talk, she shed light on the possible mechanisms of insulin resistance.